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Engineered probiotics equipped with a synthetic glucose-responsive circuit transiently colonize the gut and secrete therapeutic factors when glucose levels increase, enabling safe, oral, sense-and-respond control of diabetes in mouse and primate models.
RGP lineage tracing in stem-cell-derived organoids shows highly plastic proliferation and reduced clonal neuronal diversity, indicating that missing non-cell-autonomous niche cues are essential for faithful temporal control of cortical lineage progression.
Tracing cascading continental-scale medieval megafloods across Europe indicates that current flood management is unprepared for such sequences, highlighting the urgent need for proactive flood risk management strategies that account for unusual series of extreme flood events.
CDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle arrest.
Expression of Meis2 in hippocampal parvalbumin-expressing interneurons in an adult mouse model of neurodevelopmental disorders rescues experience-dependent plasticity, improves memory and network function and suppresses seizures.
Observations of an unusual cosmic-dawn source illuminate how early supermassive black holes may have grown rapidly in a gas-enshrouded state; such enshrouded black holes may lie at the heart of the 'little red dots'.
Global photovoltaic waste will reach 297–402 million tonnes by 2060, and regionally adapted recycling strategies and international cooperation will be needed to provide equitable and scalable PV waste circularity.
A new chemistry-based super-resolution imaging framework is described, enabling 3D, laser-free, highly sensitive and ultralong-term imaging of live cells which overcomes the limitations in spatiotemporal resolution associated with reaction-based imaging methods.
By engineering the statistics of light at the micrometre scale using phase-only spatial light modulators, both the state and degree of polarization become spatially programmable, enabling direct encoding of information in a high-dimensional space.
Behaviour of human participants in a prey-pursuit task reflects dynamic blending of goal-specific control policies, with hippocampus estimating latent states, anterior cingulate cortex orchestrating policy switches and orbitofrontal cortex supplying value-based contextualization rather than driving continuous policy updating.
Cryo-electron microscopy structures show how IS621 bridge recombinase mediates DNA excision, explaining its natural preference for insertion and informing the design of programmable bridge-editing technologies.
Substantial intraspecific variation, together with species turnover, drives coordinated shifts in drought resistance such as increased embolism resistance and wider stomatal safety margins in drier forests.
Shocks in the eastern outskirts of the Helix Nebula, detected in Hα emission with the MOTHRA telescope, provide evidence for the recycling of fragmented stellar ejecta into the surrounding gas.
Deep Hubble Space Telescope imaging of the ultra-diffuse galaxy UGC 9050-Dw1 reveals an extragalactic globular cluster stream, with analysis and modelling probing the rich dark matter content of the host galaxy.
