npj Systems Biology and Applications

A computational framework for discovering novel synergistic drug combinations

MTOR-oriented drug combinations for colorectal cancer

Featured

Biological oscillations without intracellular oscillator or external forcing

Vincent Vandenbroucke
Lucas Henrion
Frank Delvigne
ArticleOpen Access05 Aug 2026
Spatial modelling of NOTCH signalling predicts tuneable dynamic heterogeneity in endothelia

Francois Chesnais
Jonas Hue
Lorenzo Veschini
ArticleOpen Access23 Jul 2026
Wrapshap a high dimension feature selection framework to explore biological systems through machine learning explanations

Félix Furger
Miguel Thomas
Paul Monsarrat
ArticleOpen Access21 Jul 2026
Metabolic set theory: a generalized model of microbial interactions

Jyoti Jyoti
Hannah Zoller
Marc-Thorsten Hütt
ArticleOpen Access01 Jul 2026

Announcements

Congratulations to Prof. Réka Albert!

We are excited to share that one of our Associate Editors Prof. Réka Albert (Pennsylvania State University) has been elected to the National Academy of Sciences.
Call for papers: Modeling in Mathermatical Oncology

This Collection invites research on recent methods and applications in mathematical oncology that lead to mechanistic insight into cancer dynamics through integration of mathematics or artificial intelligence with multiscale multimodal data.

Open for submissions
Call for papers: Towards Ai-enhanced synthetic biology

This collection invites contributions on experimental, computational and theoretical work applying advances in artificial intelligence to the field of synthetic biology.

Open for submissions
Call for papers: Spatial Biology Across Scales

This Collection invites Articles, Letters, Reviews, and Perspectives that advance our understanding of spatial biology through experimental, computational, or theoretical lenses. We particularly welcome studies that bridge experimental and computational p

Open for submissions

Browse articles

Comparative transcriptomic analysis reveals distinct ER stress responses in tunicamycin sensitive and resistant CHO cells

Priya Mishra
Sarika Mehra
ArticleOpen Access12 Sept 2026
Residual demand bias across regulatory layers in Escherichia coli

Chikoo Oosawa
ArticleOpen Access08 Sept 2026
Dynamic regulation of a domesticated DNA transposon-derived gene, in human germline and early embryonic development

Tanuja Bhardwaj
Sharmistha Majumdar
ArticleOpen Access08 Sept 2026
Shared immune core genes in nonalcoholic steatohepatitis and primary biliary cholangitis

Min Zhou
Min Chen
Jinwen Zhao
ArticleOpen Access04 Sept 2026
Comparative modelling of large-scale 3D genome re-arrangements in different viral infections

Andrea Fontana
Simona Bianco
Andrea M. Chiariello
ArticleOpen Access04 Sept 2026
Network analysis and drug repurposing reveal targets for combination therapy in drug resistant breast cancer

Najmeh Fattahi
Changiz Eslahchi
Soroush Sardari
ArticleOpen Access03 Sept 2026
Profiling of pyrimidine and arginine metabolism in NSCLC identified Malate-Aspartate Shuttle as the backbone network

Muhammad Ayaz Anwar
Su-Jung Kim
Kwang Pyo Kim
ArticleOpen Access02 Sept 2026
The effects of a coherent feed-forward loop on Turing pattern formation in the Gierer-Meinhardt model

Yamen Alharbi
ArticleOpen Access02 Sept 2026
Robust calibration of generalised Lotka-Volterra models

Ana Paredes-Vázquez
Eva Balsa-Canto
Julio R. Banga
ArticleOpen Access02 Sept 2026

Trending - Altmetric

Science jobs

Postdoctoral Scholar in Visual System Neurobiology & Multi-Omics

We are seeking a highly motivated scientist trained in neuroscience with expertise in molecular biology and bioinformatics

Los Angeles, California

University of California Los Angeles
Faculty Positions (Life Science and Technology)

The School of Life Science and Technology (SLST) invites applications for numerous tenure-track and tenured positions.

Shanghai (CN)

ShanghaiTech University
Faculty Positions in AI for Life Sciences at Westlake University

Invites applications for tenure-track or tenured faculty positions at all academic ranks in the field of artificial intelligence for life sciences.

Hangzhou, Zhejiang (CN)

Westlake University School of Life Science
Principal Investigator and Postdoctoral Positions at Chinese Institute for Medical Physiology, CIMR

Chinese Institute for Medical Physiology at CIMR in Beijing, China, is expanding its recruitment of PIs at all ranks and postdoctoral fellows.

Beijing (CN)

The Chinese Institutes for Medical Research (CIMR), Beijing
Assistant Professor (Tenure-Track) Faculty Position

Tenure track Assistant Professor position in Pharmaceutical Sciences at the University of Michigan

Ann Arbor, Michigan

University of MI- College of Pharmacy

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

MTOR-oriented drug combinations for colorectal cancer

Featured

Biological oscillations without intracellular oscillator or external forcing

Spatial modelling of NOTCH signalling predicts tuneable dynamic heterogeneity in endothelia

Wrapshap a high dimension feature selection framework to explore biological systems through machine learning explanations

Metabolic set theory: a generalized model of microbial interactions

Announcements

Congratulations to Prof. Réka Albert!

Call for papers: Modeling in Mathermatical Oncology

Call for papers: Towards Ai-enhanced synthetic biology

Call for papers: Spatial Biology Across Scales

Browse articles

Comparative transcriptomic analysis reveals distinct ER stress responses in tunicamycin sensitive and resistant CHO cells

Residual demand bias across regulatory layers in Escherichia coli

Dynamic regulation of a domesticated DNA transposon-derived gene, in human germline and early embryonic development

Shared immune core genes in nonalcoholic steatohepatitis and primary biliary cholangitis

Comparative modelling of large-scale 3D genome re-arrangements in different viral infections

Network analysis and drug repurposing reveal targets for combination therapy in drug resistant breast cancer

Profiling of pyrimidine and arginine metabolism in NSCLC identified Malate-Aspartate Shuttle as the backbone network

The effects of a coherent feed-forward loop on Turing pattern formation in the Gierer-Meinhardt model

Robust calibration of generalised Lotka-Volterra models

Trending - Altmetric

Science jobs

Postdoctoral Scholar in Visual System Neurobiology & Multi-Omics

Faculty Positions (Life Science and Technology)

Faculty Positions in AI for Life Sciences at Westlake University

Principal Investigator and Postdoctoral Positions at Chinese Institute for Medical Physiology, CIMR

Assistant Professor (Tenure-Track) Faculty Position

Search

Quick links

Featured

Announcements

Advertisement

Trending - Altmetric

Assessment of plasma derived microbiome profiles in lung cancer using targeted and whole exome sequencing

Characterizing open-ended evolution through undecidability mechanisms in random Boolean networks

Bacterial and fungal communities and network dynamics in Otitis media patients upon 1,8-Cineol treatment

Canalization as a stabilizing principle of gene regulatory networks: a discrete dynamical systems perspective

Search

Quick links