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Lihao Yin

and 3 more

Generative retrieval reframes information access as sequence generation: a model emits document identifiers that are subsequently mapped to corpus items. Contemporary systems such as DSI-style retrieval and structured approaches like SEATER demonstrate that learned identifiers can act as effective addresses, but they remain only weakly grounded in the actual geometry and topology of the corpus. In this paper we introduce spectral-aware unique identifiers: composite codes that pair a simple integer ID with an order key derived from taumode-a spectral energy and manifold-aware proximity functional computed by ArrowSpace from graph Laplacians and eigenspaces. Rather than treating identifier tokens themselves as the semantic space, we treat taumode as the retrieval-native latent manifold and use external IDs as thin pointers into it. Taumode summarizes each document into spectral coordinates, energy levels, and graph-consistent neighborhoods, yielding a geometry where similarity, locality, and diffusion are explicit rather than emergent, and where the identifier order is aligned with the spectral energy landscape. In this view ArrowSpace serves both vector search and generative retrieval as a spectral index that provides a mathematically grounded geometry for identifier design, constrained decoding, candidate generation, and reranking. We define a concrete identifier scheme (ℓ i , u i) based on λ τ values and prove that it preserves manifold structure more faithfully than sequence-only identifiers, while remaining compatible with autoregressive models. We substantiate the advantages of spectral-aware IDs over current generative retrieval signals in terms of manifold consistency, interpretability, locality preservation, robustness under structural perturbation, and ease of integration into existing vector databases and generative search pipelines.

Victor I. Mwangi

and 10 more

Aims: This study investigated whether common CYP3A4 and CYP3A5 variants are associated with clinical outcomes in hospitalized COVID-19 patients treated with MP in Manaus, Brazil. Methods: A pharmacogenetic analysis was conducted on 100 hospitalized COVID-19 patients enrolled in a randomized, placebo-controlled clinical trial receiving heavy-dose intravenous MP (n = 49) or placebo (n = 51), for five days. CYP3A4: c.-392G>A (rs2740574, CYP3A4*1.002) and CYP3A5 (rs776746 - *3 and rs10264272 - *6) variants were genotyped. Associations between genotypes, treatment outcomes, and time to discharge or death were analyzed using χ 2 tests, Kaplan-Meier curves, and Cox regression. Results: Allele frequencies of CYP3A4*1.002 (86%), CYP3A5*3 (70%), and CYP3A5*6 (2%) were within those reported in admixed Latin American populations . Genotype distributions did not differ significantly between treatment groups or outcome categories. Carriers of CYP3A5 wild-type (*1/*1) genotypes had shorter hospital stay (p = 0.012), and this genotype did not influence mortality. Adjusted Cox models showed only sex, comorbidities, and weight predicted discharge likelihood in both CYP3A4 and CYP3A5 models (p<0.05). Conclusion: CYP3A4 and CYP3A5 variants were associated with modest differences in hospital length of stay but did not independently influence survival among MP-treated COVID-19 patients. Host genetic variation in CYP3A-mediated metabolism may contribute to variability in recovery dynamics, although clinical characteristics remained dominant determinants of clinical outcome.

Runxia Zhang

and 7 more

Small carnivores fulfill important ecological roles in forest ecosystems, yet their diel activity patterns and habitat requirements in subtropical forests remain insufficiently documented. Using 116,800 camera-trap days (2021–2024) at the Chebaling National Nature Reserve, Guangdong Province, China, we characterized the diel activity rhythms and habitat selection of four sympatric small carnivore species: the leopard cat (Prionailurus bengalensis), crab-eating mongoose (Urva urva), spotted linsang (Prionodon pardicolor), and masked palm civet (Paguma larvata). Kernel density estimation revealed distinct diel strategies among the four species. The crab-eating mongoose was strictly diurnal, while the leopard cat, spotted linsang, and masked palm civet were all nocturnal. Temporal overlap was high among nocturnal species (Δ = 0.695–0.899) but low between the diurnal mongoose and each nocturnal species (Δ = 0.074–0.371). Seasonal comparisons showed that all species except the crab-eating mongoose maintained highly consistent activity rhythms between the growing and non-growing seasons. MaxEnt modelling indicated that all four species preferred gently sloping terrain with high vegetation cover (NDVI > 0.43) near water sources. However, they differed in aspect preference, habitat breadth, and sensitivity to anthropogenic disturbance. The leopard cat occupied the largest area of suitable habitat (29.08 km²) and favored shaded slopes; the spotted linsang showed notable avoidance of roads; and the masked palm civet exhibited the broadest ecological tolerance. These results suggest that diel activity divergence between the diurnal and nocturnal guilds, together with species-specific differences in microhabitat selection among the nocturnal species, may contribute to reducing interspecific competition within this assemblage. Our findings provide baseline ecological data for the conservation management of small carnivore communities in subtropical forest ecosystems of southern China.

Fettah Khaled

and 5 more

The rapid development of distributed generation (DG) has a significant impact on modern distribution networks, providing environmental, economic, and technical benefits. At the same time, this phenomenon also poses new challenges for system protection, operation, and planning. Many studies have focused on the optimal placement and sizing of DG, but most of the existing reviews are fragmented, with most studies focusing on a specific aspect while ignoring a comprehensive analytical framework. In this sense, this research aims to provide a comprehensive, multi-faceted review on this topic, based on more than a decade of research, including technical, economic, environmental, and protection issues. A new classification framework with four dimensions is proposed for evaluating optimization methods, DG technologies, and planning strategies using a unified analytical framework. This review article presents a critical comparison of mathematical, analytical, and metaheuristic methods, which facilitates an understanding of the trade-off between different dimensions. Moreover, the article reveals the commonly overlooked effects of DG on protection coordination and system robustness. Additionally, the article presents potential research directions for protection-aware and multi-objective optimization. The research reveals that the effectiveness of the integrated planning approach, which considers network constraints, the variability of renewable sources, and multi-scenario operation, is vital to maximize the positive effects of DG. This article presents an integrated guideline for researchers and practitioners, which clearly explains the challenges, existing gaps, and new opportunities that will define the future of the distribution network with the integration of DG.

Dmitry Rodin

and 1 more

We present LiveFace, a modular neural rendering system that achieves photorealistic talking-head animation at 30 fps on low-end mobile devices with as little as ~10 GFLOPS of compute (e.g., Qualcomm Snapdragon 439). Prior photorealistic facial animation systems either require cloud infrastructure with 100M+ parameter models (HeyGen, DID , Synthesia) or demand desktop-class GPUs (MetaHuman, Audio2Face), while on-device alternatives sacrifice realism for stylized cartoon aesthetics (Apple Memoji, Samsung AR Emoji). LiveFace bridges this gap through three key contributions: (1) a decomposed per-avatar decoder architecture that factorizes the face into four independently rendered regions-mouth, eyes, hair, and body-each handled by a compact neural decoder (1.3-5.7M parameters) augmented with a 128-dimensional learnable identity embedding; (2) a universal compositor-upscaler (~7M parameters) shared across all avatars that composites the decoded patches onto a 9:16 portrait canvas and upscales to 360x640 (or 384x672) in a single forward pass; and (3) a videodriven knowledge distillation pipeline that uses RAVDESS emotional speech videos as driving sources for LivePortrait (~300M parameters) to generate diverse, naturalistic training data for the student decoders. The MouthDecoder supports dual-input conditioning: both viseme-based (audio-driven) and landmark-based (MediaPipe Face Mesh) modes, enabling flexible integration with different upstream pipelines. A perframe quality filter employing Haar cascade face detection, Laplacian blur scoring, and SSIM comparison ensures training data integrity by rejecting approximately 0.6% of generated frames. A working V3 prototype has been trained and validated, demonstrating that the architecture successfully produces photorealistic output from compact per-avatar models. The full system comprises ~20M INT8 parameters with a 08.04.2026, 02:01 file:///C:/Users/123/AppData/Local/Temp/arxiv_paper_liveface_v2_EN.html 1/23 total inference latency of ~19 ms per frame, enabling real-time, fully offline operation on commodity mobile hardware without any cloud dependency.

Emma Bagnoli

and 4 more

Background: Intraluminal small intestinal obstructions (ISIO) are common in the United Kingdom, but most published studies are from North America. Objectives: To describe ISIO prevalence among all colic cases undergoing laparotomy at an English equine hospital between 2018 and 2024, and to identify risk factors for developing pre-operative and post-operative reflux (POR) and survival. Study design: Retrospective cohort study. Methods: Data on age, breed, gender, heart rate (HR), PCV, total solids concentration (TS), serum lactate and peritoneal lactate concentrations on presentation, development of pre-operative reflux and POR, complications (thrombophlebitis, sepsis, ileus, laminitis, surgical-site infection), duration of hospitalisation and survival to discharge were obtained. Univariable logistic regression was used to investigate the relationship between these parameters and development of POR and survival to discharge. Results: Thirty-three patients met the inclusion criteria. ISIO prevalence was 7.2% (95%CIs:5.2%-9.8%). At presentation mean HR was 55bpm (36-96bpm), PCV was 37% (28-52%), TS was 69g/L (52-86g/L), serum lactate concentration was 2.6mmol/L (0.5-15.7mmol/L) and abdominal lactate concentration was 6mmol/L (0.7-22.3mmol/L). Nasogastric reflux on presentation was seen in 5/33 patients, 9/33 developed POR and 25/33 survived to discharge. Mean hospitalisation time was 10 days (3-38 days). For each 10 units of increase in HR above 45bpm, the odds of developing POR increased 2.05-fold (p=0.025; 95%CIs:0.99-4.26). Horses that survived were significantly less likely to have developed POR than non-survivors (p<0.001; OR:0.03; 95%CIs:0.003-0.22) or post-operative complications (p<0.001; OR:0.04; 95%CIs:0.004-0.405). Main limitations: retrospective, single-centre design. Conclusions: ISIO prevalence in England aligns with North America. High HR on admission is related to POR and development of POR is associated with reduced survival.

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Ramesh Wilson

and 5 more

Coastal ecosystems are exposed to both global and local stressors operating across multiple scales. However, research rarely considers how their combined effects propagate over time and across levels of biological organisation. Here, we employ an in situ warming experiment across two rocky shore sites with contrasting sewage pollution to quantify independent and interactive effects of warming and nutrient pollution from genes to communities. Passively warmed and control settlement plates were deployed at polluted and non-polluted sites and surveyed across a summer to quantify temporal dynamics in the responses of key intertidal taxa. Barnacles were further employed as a model for comparing responses across biological levels, including body size, stable isotope analysis, and RNA sequencing. Pollution consistently increased invertebrate abundance and macroalgal cover, alongside transient positive effects on barnacle size, whereas warming reduced barnacle abundance and suppressed macroalgal cover late in the season. Warming and pollution interacted synergistically on barnacle abundance, with pollution remaining the dominant stressor. Microphytobenthos groups similarly showed distinct pollution-driven increases with warming primarily modifying temporal trajectories; cyanobacteria showed both date-specific and season-wide synergistic interactions, against a backdrop of temporal variability across stressor treatments. Consistent with these patterns, pollution shifted barnacle δ13C and δ15N toward values indicative of greater assimilation of sewage-derived material, while warming increased elemental C:N ratios, consistent with altered nutritional stress. Transcriptomic responses mirrored this dominance of pollution, broadly regulating gene expression linked to protein turnover, DNA repair, and protein folding; combined warming and pollution further intensified proteostasis-related changes and produced predominantly reversal and antagonistic interaction types. Our results show that sewage pollution can overwhelm and reshape warming effects over time and across biological levels, linking group-level responses with parallel shifts in trophic biomarkers and gene regulation. Our scalable field approach provides a template for in situ marine multiple stressor experiments across wider spatiotemporal scales.

Xiaoyun Liang

and 1 more

Widespread acceptance of collaborative robots in human-involved scenarios requires accessible and intuitive interfaces for lay workers and non-expert users. Existing interfaces often rely on users to plan and issue low-level commands, necessitating extensive knowledge of robot control. This study proposes a multimodal Agentic AI framework integrating natural user interfaces (NUIs) to foster effortless human-like partnerships in Human-Robot Collaboration (HRC). It enhances intuitiveness and operational efficiency. First, it allows users to instruct robots using plain language verbally, coupled with gaze revealing objects precisely. Second, it offloads users’ workload for robot motion planning by understanding context and reasoning task decomposition. Third, coordinating with AI agents built on large-language models (LLMs), the system interprets users’ requests effectively and provides feedback to establish transparent communication. Experiments were conducted to demonstrate a practical implementation of the Agentic AI framework on a mobile manipulation robot in the collaborative task of human-robot wood assembly. In the implementation, seven participants were recruited to interact with this AI-integrated agentic robotic system. Task performance and user experience metrics were measured in terms of completion time, intervention rate, NASA TLX survey for workload, and valuable insights of practical applications were summarized through a qualitative analysis. This study highlights the potential of NUIs and Agentic AI-embodied robots to overcome existing HRC barriers and contributes to improving HRC intuitiveness and efficiency.

A Dobrynin

and 2 more

Recent advances in deep learning and scientific machine learning (SML) offer a wide spectrum of novel tools with the potential to radically transform various areas of academic research, industrial R&D, and manufacturing. These include inverse device design, data-driven equation discovery, rapid approximate partial differential equations solutions for exploring the design space, automated metrology and manufacturing process control, new materials design, and the creation of fast and realistic digital twins for virtual testing and design optimization. The purpose of this review is to assist R&D practitioners, who are not specialists in AI, in navigating this complex and dynamic landscape, enabling them to adopt modern machine learning (ML) methods in their work. We particularly emphasize the potential advantages of deep learning methods for the field of thin film device developing, highlighting the main approaches and points of their applications in R&D design and process. The review is organized into several sections. First we provide a brief overview of machine learning and deep learning, introducing basic neural network architectures, and describing their possible use cases relevant to industrial R&D. In the following section we introduce examples of ML approaches enabling the reduction of dependency on the amount of input data and improving generalization capabilities of neural networks through introduction of realistic inductive biases in the form of symmetries, conservation laws, physics equations, etc. Then we review some of most successful large scale SML models, including foundational materials simulation and generation models. Finally, we discuss existing and prospective applications of ML models in different aspects of thin film devices development.

Neil Raymond

and 3 more

We present atmospheric chlorine inventories over twenty-one years (2004–2024) and five latitude bands (82–60°N, 60–30°N, 30°N–30°S, 30–60°S, 60–82°S) across altitudes from the surface up to 61 km. These inventories were calculated using the Atmospheric Chemistry Experiment-Fourier Transform Spectrometer (ACE-FTS) version 5.3 retrievals of the volume mixing ratios (VMRs) of 13 chlorine-containing species. Of these, five are product gases: HCl, HOCl, ClONO2, COClF, COCl2, and eight are source gases: CCl4, CH3Cl, CFC-11 (CCl3F), CFC-12 (CCl2F2), CFC-113 (CClF2CCl2F), HCFC-22 (CHF2Cl), HCFC-141b (C2H3Cl2F), and HCFC-142b (C2H3ClF2). Where necessary, ACE-FTS data were supplemented with data from the TOMCAT 3-D chemical transport model, the Aura Microwave Limb Sounder (MLS) instrument, and ground-based measurements from the National Oceanic and Atmospheric Administration (NOAA) and the Advanced Global Atmospheric Gases Experiment (AGAGE). Total chlorine (Cltot) profiles are dominated by source gas contributions in the troposphere and lower stratosphere. At lower altitudes, the primary contributions are chlorofluorocarbons (CFCs), chlorocarbons, and, increasingly in recent years, chlorine-containing very short-lived substances (Cl-VSLS). At higher altitudes, HCl becomes the dominant contributor, comprising up to 99% of Cltot by 61 km. The relative contribution of individual species to Cltot showed that Cl-VSLS and HCFC-22 have partially slowed the reduction in atmospheric chlorine achieved by the phase-out of CFC production and consumption. Between 2004 and 2024, the global mean Cltot time series decreased by 9.56 ± 0.28 ppt/year (0.28 ± 0.01 %/year), with values approaching 3.3 ppb in 2024. These findings demonstrate the significant impact of the Montreal Protocol in reducing emissions of substances that are both ozone-depleting and green-house gases.
Real time payment gateways handle authorization and clearing traffic for card and account based ecosystems under strict latency and availability targets. Most deployed gateways still rely on RSA and elliptic curve cryptography, which become vulnerable once large scale quantum computers can run Shor's algorithm. Simply swapping these algorithms for NIST standard post quantum schemes is not enough, because gateways must still meet service level agreements, maintain Payment Card Industry Data Security Standard (PCI DSS) compliance, and interoperate with acquirers and issuers that migrate at different speeds. This paper presents a Post Quantum Cryptography Migration Framework that gives an end to end architectural view of gateway, acquirer, and issuer communication paths. The framework introduces a crypto abstraction layer with pluggable algorithm providers, supports hybrid classical plus post quantum modes during transition, and uses policy driven selection of key encapsulation and signature schemes such as Kyber and Dilithium. It also defines a phased migration process from asset discovery and quantum risk assessment through controlled hybrid rollout to post quantum only operation. To validate the approach, we implement a gateway testbed that replays a PaySim transaction workload and measure the impact of post quantum schemes on authorization latency and derived throughput under classical only, hybrid, and PQC only modes. The experiments show that, with careful configuration and connection management, post quantum protection can be integrated into real time payment processing with performance overhead kept within operational limits.

Marius Meiswinkel

and 2 more

Condition monitoring and predictive maintenance of large hydro and wind generators are essential for reducing operational costs and improving system availability. However, traditional monitoring approaches rely primarily on stator-side measurements and bearing vibrations, providing limited observability of rotor-side phenomena where many critical faults originate. This paper presents a comprehensive modular contactless telemetry system designed for direct rotor-side measurement of multiple physical quantities including magnetic flux density, temperatures, damper winding currents, and mechanical vibrations. The system architecture prioritizes flexibility and scalability, enabling easy integration of different sensor types with configurable sampling rates and resolutions. In a laboratory research environment, fixed sensor configurations and rigid sampling parameters often become limiting factors. The proposed modular design addresses these constraints by allowing users to dynamically add or remove acquisition modules, adapt sampling parameters for specific experiments, and perform on-rotor preprocessing to optimize data transmission bandwidth. Detailed descriptions of the hardware design, synchronization strategy, communication protocol, and software architecture are provided. Experimental validation is demonstrated on a 366 kVA research hydro generator, demonstrating the system's capability for reliable, synchronized multi-channel acquisition on a rotating platform with contactless data transmission.

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