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National Cancer Institute

@theNCI
The U.S. government’s agency for cancer research. Part of @NIH. Engagement ≠ endorsement. Questions about cancer? Reach us here: cancer.gov/contact
Bethesda, MD
cancer.gov
Joined May 2009
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    National Cancer Institute
    @theNCI
    6h
    One of the biggest questions in translational oncology is whether we can demonstrate that cancer models can faithfully represent patient biology. A new @Nature study provides evidence that NCI's Human Cancer Models Initiative does just that. go.nih.gov/IDoYiIW
    Organoids are miniature versions of organs grown in the lab. Organoid culture systems offer a powerful platform for the development of targeted therapies and precision medicine by letting scientists easily create genetic or environmental changes (difficult or impossible in animal models or human patients) to identify networks of genes that control cellular behaviors that give way to tumors. This image shows an organoid that was grown from a single mammary stem cell. Researchers used this system to demonstrate how a single critical gene, called Sox10 (in blue), controls whether cells turn into dangerous mini \"factories\", rapidly churning out more copies and variants of themselves. The Sox10 gene allows cells to migrate and to take on characteristics of other cells (plasticity). In cancer cells, these features lead to metastasis and drug resistance. Inner keratin-8+ luminal cells (in green) are surrounded by peripheral keratin-14+ basal cells (in red).
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    National Cancer Institute
    @theNCI
    Aug 12
    An NCI-led analysis of 1.4 million cancer diagnoses among older adults found cancer-related medical costs were highest in the year before a cancer death—about $122,000 more than for similar people without cancer. Read more: go.nih.gov/OIcCW1h
    Two older adults converse over a laptop and documents.
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    National Cancer Institute
    @theNCI
    Aug 12
    🧵 (1/5) Stay connected to the latest cancer research and resources through these upcoming NCI events covering early career cancer research, emerging science, cancer progression, and proteogenomics.
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    National Cancer Institute
    @theNCI
    Aug 7
    🏆 Introducing the NCI Office of Data Sharing (ODS) Impact Prize—a $200,000 challenge recognizing ideas and exemplars that advance the sharing and reuse of cancer research outputs! Join our pre-submission webinar on August 12, 1:00–2:00 PM ET. Register for the webinar:
    A banner reads, \"National Cancer Institute. Office of Data Sharing. Impact Prize. Turning cancer research into meaningful community impact.\"