There is progress to report on the U.K. government’s commitment to reduce the use of animals in research, with the formation of a new national center to validate and standardize patient-derived organoids.
There is progress to report on the U.K. government’s commitment to reduce the use of animals in research, with the formation of a new national center to validate and standardize patient-derived organoids.
Three months on, the emergency response to block transmission of the Bundibugyo Ebola virus in the Democratic Republic of Congo (DRC) is failing to stop its spread and at the current rate the outbreak will eclipse that in West Africa, 2014-2016, which is the deadliest to date. The fragility of the healthcare system in DRC, an active armed conflict and a highly mobile population are among the factors driving this.
Arisan Therapeutics Inc. has been selected for a contract award from the National Institute of Allergy and Infectious Diseases (NIAID) to support the development of its lead compound, an orally administered, broad-spectrum, small-molecule antiviral candidate for Ebola virus disease.
A quarterly dynamic table featuring new molecular entities (NMEs) revealed for the first time in current literature, at congresses and in company communications during the quarter.
In a recent study published in Molecular Therapy Oncology, researchers from the Technische Universität Berlin (Germany) and collaborating institutions aimed to enhance the therapeutic efficacy of PD-H in colorectal cancer by inserting Neo-2/15 as an immunomodulatory transgene.
Dogwood Therapeutics Inc. disclosed in its earnings report that the company has obtained IND approval from the FDA for SP-16 for the treatment of chemotherapy-induced pain and peripheral neuropathy.
Jiangsu Hengrui Pharmaceuticals Co. Ltd. and Shanghai Hengrui Pharmaceutical Co. Ltd. have identified proteolysis targeting chimera (PROTAC) compounds reported to be useful for the treatment of cancer and autoimmune disease.
Histone acetyltransferase KAT6A is a modulator of gene expression in cancer and hematopoietic cells, thus being an epigenetic target in cancer therapy. KAT6A inhibitors are used in breast cancer therapy, but some of them such as prifetrastat are associated with on-target toxicity including...
Shy Therapeutics LLC has developed and presented data for SHY-ONC6, a novel inhibitor of the proteasome 19S regulator particle (RP) ATPases for the potential treatment of hematological malignancies such as multiple myeloma and mantle-cell lymphoma, as well as solid tumors.
The scientific community continues to make progress at uncovering the elements that could lead to a cure for HIV. The virus remains latent in reservoirs that are difficult to eliminate, so researchers are pursuing two main strategies. The “shock-and-kill” approach aims to wake up latent virus and...
University of Miami and Starx Therapeutics Inc. have presented data on UMF-814A, a STK17A inhibitor with promising activity in myelodysplastic syndrome and acute myeloid leukemia.
Colorectal cancer (CRC) remains a leading cause of cancer-related death globally. Annexins are a superfamily of calcium-dependent phospholipid-binding proteins that are widely expressed in various tissues. Among these proteins, annexin A11 (ANXA11) plays a role in tumor progression by modulating...
Shanghai Ark Biopharmaceutical Co. Ltd. has obtained clinical clearance from China’s National Medical Products Administration (NMPA) for AK-0406 injection, the company’s first long-acting antiviral drug-Fc conjugate candidate for influenza prophylaxis.
Invasive fungal infections (IFIs) are a group of diseases with high incidence and mortality rates and are caused by opportunistic pathogens such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. Starting from the lead compound iodiconazole, researchers from the China...
Acurx Pharmaceuticals Inc. has established a new scientific partnership with Leiden University Medical Center to advance development of Acurx’s DNA polymerase IIIC (pol IIIC) inhibitor antibiotics.
An experimental cell therapy based on regulatory T cells (Tregs) engineered with a chimeric antigen receptor (CAR) recognizes a pathogenic form of α-synuclein in Parkinson's disease (PD). In two mouse models of PD, the CAR-Tregs reduced T cell-mediated inflammation, limited neurodegeneration and...
Diamond Therapeutics Inc. has discovered 5-HT2A and/or 5-HT2C receptor agonists potentially useful for the treatment of epilepsy, pain, and tuberous sclerosis as well as cognitive, neurobehavioral, and mood disorders.
Remedium Bio Inc. has announced the initial closing of its planned $10 million series A financing as it advances its durable protein therapeutics platform toward first-in-human development.
Oculis Holding AG and Accure Therapeutics SL have entered into an asset purchase agreement whereby, upon closing, Oculis will acquire all of Accure’s worldwide development and commercial rights to privosegtor (ACT-01), and in a separate closing, ACT-02, an early-stage preclinical neurology drug...
Vanderbilt University researchers have reported data on a brain-penetrant, mGlu2 receptor negative allosteric modulator (NAM), VU-6066098, for the potential treatment of neurological and psychiatric disorders.
Evopoint Biosciences Co. Ltd. has divulged dihydropyrazolopyridinone compounds acting as 2-acylglycerol O-acyltransferase 2 (MOGAT2) inhibitors reported to be useful for the treatment of obesity, metabolic syndrome and more.
Respiratory syncytial virus (RSV) infection is responsible for 3.2 million hospital admissions and about 118,000 deaths in children under 5 years of age. The increased risk of RSV infection (and other infectious diseases) in young children is broadly attributed to their immature immune system. But...
In a recent study, researchers from Washington University School of Medicine and collaborators analyzed cross-sectional blood samples to identify circRNAs associated with Alzheimer’s disease (AD) clinical status, amyloid-β and tau stages, and progression to symptomatic AD.
Shanghai Longke Pharmaceutical Co. Ltd. has disclosed 17-β-hydroxysteroid dehydrogenase 13 (HSD17B13; 17-β-HSD 13) inhibitors reported to be useful for the treatment of liver diseases.
Chronic liver injury promotes hepatic fibrosis through the activation of hepatic stellate cells and excessive extracellular matrix deposition, a process that can progress to cirrhosis and liver cancer. Researchers from Xiamen University used...
Although antiretroviral therapy (ART) can suppress HIV to undetectable levels, a growing body of evidence suggests that the virus leaves a lasting biological imprint. At the 26th International AIDS Conference (AIDS 2026), researchers reported...
Chinese researchers have reported the discovery and preclinical characterization of a series of novel ibuprofen derivatives designed to modulate MAPK signaling and restore intestinal immune homeostasis.
U&S Bio Co. Ltd. has divulged H+/K+-ATPase inhibitors with improved stability found to be potentially useful for the treatment of gastrointestinal disorders, cancer, Helicobacter pylori infection, sialorrhea, asthma and airways obstruction, among...
Cancer researchers are increasingly turning to the microbiome to understand why some patients respond well to treatment while others face severe complications. Gut microbial communities shift during intensive therapies such as bone marrow...
Understand the present and future of drug and medical technology innovation with our premium videos and podcasts, produced for biotechnology, pharmaceutical and healthcare technology professionals. Featuring exclusive interviews with industry pioneers, executives, regulatory experts and leading researchers, our multimedia content translates complex news into actionable insights shaping the future of patient care.
Understand the present and future of drug and medical technology innovation with our premium videos and podcasts, produced for biotechnology, pharmaceutical and healthcare technology professionals. Featuring exclusive interviews with industry pioneers, executives, regulatory experts and leading researchers, our multimedia content translates complex news into actionable insights shaping the future of patient care.