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Comment
. 2017 Jul 11;114(28):7194-7196.
doi: 10.1073/pnas.1709067114. Epub 2017 Jun 29.

Tracking LINE1 retrotransposition in the germline

P Jeremy Wang  1
Affiliations
Comment

Tracking LINE1 retrotransposition in the germline

P Jeremy Wang. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Dynamics of piRNAs, DNA methylation, histone modification, and LINE1 activity during mouse male germ-cell development. Two populations of piRNAs (prepachytene and pachytene) are shown. Prepachytene piRNAs are mostly derived from transposable elements, whereas the majority of pachytene piRNAs are derived from nonrepetitive regions. Crosses on the lines mark the time point of meiotic arrest in Mov10l1−/− and Mili−/− males (13, 20). Data from Newkirk et al. (4) support that H3K9me2 expression pattern in Mov10l1−/− testis is similar to that in Mili−/− testis (depicted here) (9). The figure is modified from figure 1 in ref. .
See this image and copyright information in PMC

Comment on

  • Intact piRNA pathway prevents L1 mobilization in male meiosis.
    Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, An W. Newkirk SJ, et al. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5635-E5644. doi: 10.1073/pnas.1701069114. Epub 2017 Jun 19. Proc Natl Acad Sci U S A. 2017. PMID: 28630288 Free PMC article.

References

    1. Huang CR, Burns KH, Boeke JD. Active transposition in genomes. Annu Rev Genet. 2012;46:651–675. - PMC - PubMed
    1. Goodier JL, Kazazian HH., Jr Retrotransposons revisited: The restraint and rehabilitation of parasites. Cell. 2008;135:23–35. - PubMed
    1. Mandal PK, Kazazian HH., Jr SnapShot: Vertebrate transposons. Cell. 2008;135:192–192.e1. - PubMed
    1. Newkirk SJ, et al. Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci USA. 2017;114:E5635–E5644. - PMC - PubMed
    1. Ostertag EM, et al. A mouse model of human L1 retrotransposition. Nat Genet. 2002;32:655–660. - PubMed

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