Pathogenesis articles from across Nature Portfolio

The identification of IRAK2 deficiency reveals how impaired Myddosome signalling can paradoxically promote interferon-driven inflammation, which expands the spectrum of monogenic immune dysregulation and underscores the importance of detecting structural variants in unsolved inborn errors of immunity.

Human brain organoids reveal how Ebola virus establishes persistent infection within the immune-privileged environment of the central nervous system.

The 21st International Aegean Conference on Innate Immunity showcased advances that position innate immunity as a multiscale regulatory system integrating environmental, metabolic, epigenetic and genetic inputs.

Tsiartas and Bennett discuss the discovery that atheroclerotic plaque vulnerability to rupture arises from the interaction between plaque composition and vessel biomechanics.

Two studies published in Science explore how 3D chromatin organization and structure can influence cardiac development and promote heart failure.

The identification of IRAK2 deficiency reveals how impaired Myddosome signalling can paradoxically promote interferon-driven inflammation, which expands the spectrum of monogenic immune dysregulation and underscores the importance of detecting structural variants in unsolved inborn errors of immunity.

Human brain organoids reveal how Ebola virus establishes persistent infection within the immune-privileged environment of the central nervous system.