FlatMux is an optimized microscope system for multiplexed two-photon imaging of neuronal activity with genetically encoded voltage sensors. The flexible system is demonstrated in a variety of scenarios in the mouse brain including a large field of view, deep imaging or two-plane imaging.

A little more than one year ago, Nature Methods rolled out a program to formally recognize early-career researcher contributions to our peer review process. Here we provide an update on the program’s success.

Biologists can reuse, remix and vibe code scientific figures.

Two scientists blend their love of music and science in different ways.

Voltage imaging across much of the zebrafish brain is achieved at 200.8 Hz, by optimizing a remote-scanning light-sheet microscope.

A Kaggle challenge for particle picking in experimental cryo-electron tomography data delivered new machine learning algorithms that outperformed state-of-the-art software and provides a critical reference point to benchmark future annotation tools.

This Article demonstrates that direct preference optimization (DPO) can be used to effectively align an unsupervised structure-conditioned language model with biophysical information. The aligned model, ProteinDPO, achieves stability prediction competitive with that of task-specific models and consistently outperforms unsupervised and fine-tuned versions of the model.

kpiCells are a biomimetic artificial cell system to investigate mechanoregulation in cell–cell interactions.

GHT-SELEX—high-throughput SELEX with fragmented genomic DNA—shows that transcription factors can be rather particular about which genomic loci they bind, and that C2H2 zinc finger proteins often engage different fingers at different sites.

SpaMTP enables comprehensive joint analysis of spatial metabolomics and transcriptomics data.

Biologists can reuse, remix and vibe code scientific figures.

A little more than one year ago, Nature Methods rolled out a program to formally recognize early-career researcher contributions to our peer review process. Here we provide an update on the program’s success.